This machine is suitable for packing blisters, tubes, ampules and other related objects into boxes. This machine can fold leaflet, open box, insert blister into box, emboss batch number and close box automatically. It adopts frequency inverter to adjust speed, human machine interface to operate, PLC to control and photoelectric to supervise and control each station the reasons automatically, which can solve the troubles in time. This machine can be used separately and also can be linked with other machines to be a production line. This machine can also be equipped with hot melt glue device to do hot melt glue sealing for box.